LOCUS       NC_000004              11730 bp    DNA     linear   CON 06-JUN-2016
DEFINITION  Homo sapiens chromosome 4, GRCh38.p7 Primary Assembly.
ACCESSION   NC_000004 REGION: complement(177430774..177442503) GPC_000001296
VERSION     NC_000004.12  GI:568815594
DBLINK      BioProject: PRJNA168
            Assembly: GCF_000001405.33
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11730)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
REFERENCE   2  (bases 1 to 11730)
  CONSRTM   International Human Genome Sequencing Consortium
  TITLE     Finishing the euchromatic sequence of the human genome
  JOURNAL   Nature 431 (7011), 931-945 (2004)
   PUBMED   15496913
REFERENCE   3  (bases 1 to 11730)
  AUTHORS   Lander,E.S., Linton,L.M., Birren,B., Nusbaum,C., Zody,M.C.,
            Baldwin,J., Devon,K., Dewar,K., Doyle,M., FitzHugh,W., Funke,R.,
            Gage,D., Harris,K., Heaford,A., Howland,J., Kann,L., Lehoczky,J.,
            LeVine,R., McEwan,P., McKernan,K., Meldrim,J., Mesirov,J.P.,
            Miranda,C., Morris,W., Naylor,J., Raymond,C., Rosetti,M.,
            Santos,R., Sheridan,A., Sougnez,C., Stange-Thomann,N.,
            Stojanovic,N., Subramanian,A., Wyman,D., Rogers,J., Sulston,J.,
            Ainscough,R., Beck,S., Bentley,D., Burton,J., Clee,C., Carter,N.,
            Coulson,A., Deadman,R., Deloukas,P., Dunham,A., Dunham,I.,
            Durbin,R., French,L., Grafham,D., Gregory,S., Hubbard,T.,
            Humphray,S., Hunt,A., Jones,M., Lloyd,C., McMurray,A., Matthews,L.,
            Mercer,S., Milne,S., Mullikin,J.C., Mungall,A., Plumb,R., Ross,M.,
            Shownkeen,R., Sims,S., Waterston,R.H., Wilson,R.K., Hillier,L.W.,
            McPherson,J.D., Marra,M.A., Mardis,E.R., Fulton,L.A.,
            Chinwalla,A.T., Pepin,K.H., Gish,W.R., Chissoe,S.L., Wendl,M.C.,
            Delehaunty,K.D., Miner,T.L., Delehaunty,A., Kramer,J.B., Cook,L.L.,
            Fulton,R.S., Johnson,D.L., Minx,P.J., Clifton,S.W., Hawkins,T.,
            Branscomb,E., Predki,P., Richardson,P., Wenning,S., Slezak,T.,
            Doggett,N., Cheng,J.F., Olsen,A., Lucas,S., Elkin,C.,
            Uberbacher,E., Frazier,M., Gibbs,R.A., Muzny,D.M., Scherer,S.E.,
            Bouck,J.B., Sodergren,E.J., Worley,K.C., Rives,C.M., Gorrell,J.H.,
            Metzker,M.L., Naylor,S.L., Kucherlapati,R.S., Nelson,D.L.,
            Weinstock,G.M., Sakaki,Y., Fujiyama,A., Hattori,M., Yada,T.,
            Toyoda,A., Itoh,T., Kawagoe,C., Watanabe,H., Totoki,Y., Taylor,T.,
            Weissenbach,J., Heilig,R., Saurin,W., Artiguenave,F., Brottier,P.,
            Bruls,T., Pelletier,E., Robert,C., Wincker,P., Smith,D.R.,
            Doucette-Stamm,L., Rubenfield,M., Weinstock,K., Lee,H.M.,
            Dubois,J., Rosenthal,A., Platzer,M., Nyakatura,G., Taudien,S.,
            Rump,A., Yang,H., Yu,J., Wang,J., Huang,G., Gu,J., Hood,L.,
            Rowen,L., Madan,A., Qin,S., Davis,R.W., Federspiel,N.A.,
            Abola,A.P., Proctor,M.J., Myers,R.M., Schmutz,J., Dickson,M.,
            Grimwood,J., Cox,D.R., Olson,M.V., Kaul,R., Raymond,C., Shimizu,N.,
            Kawasaki,K., Minoshima,S., Evans,G.A., Athanasiou,M., Schultz,R.,
            Roe,B.A., Chen,F., Pan,H., Ramser,J., Lehrach,H., Reinhardt,R.,
            McCombie,W.R., de la Bastide,M., Dedhia,N., Blocker,H.,
            Hornischer,K., Nordsiek,G., Agarwala,R., Aravind,L., Bailey,J.A.,
            Bateman,A., Batzoglou,S., Birney,E., Bork,P., Brown,D.G.,
            Burge,C.B., Cerutti,L., Chen,H.C., Church,D., Clamp,M.,
            Copley,R.R., Doerks,T., Eddy,S.R., Eichler,E.E., Furey,T.S.,
            Galagan,J., Gilbert,J.G., Harmon,C., Hayashizaki,Y., Haussler,D.,
            Hermjakob,H., Hokamp,K., Jang,W., Johnson,L.S., Jones,T.A.,
            Kasif,S., Kaspryzk,A., Kennedy,S., Kent,W.J., Kitts,P.,
            Koonin,E.V., Korf,I., Kulp,D., Lancet,D., Lowe,T.M., McLysaght,A.,
            Mikkelsen,T., Moran,J.V., Mulder,N., Pollara,V.J., Ponting,C.P.,
            Schuler,G., Schultz,J., Slater,G., Smit,A.F., Stupka,E.,
            Szustakowski,J., Thierry-Mieg,D., Thierry-Mieg,J., Wagner,L.,
            Wallis,J., Wheeler,R., Williams,A., Wolf,Y.I., Wolfe,K.H.,
            Yang,S.P., Yeh,R.F., Collins,F., Guyer,M.S., Peterson,J.,
            Felsenfeld,A., Wetterstrand,K.A., Patrinos,A., Morgan,M.J., de
            Jong,P., Catanese,J.J., Osoegawa,K., Shizuya,H., Choi,S. and
            Chen,Y.J.
  CONSRTM   International Human Genome Sequencing Consortium
  TITLE     Initial sequencing and analysis of the human genome
  JOURNAL   Nature 409 (6822), 860-921 (2001)
   PUBMED   11237011
  REMARK    Erratum:[Nature 2001 Aug 2;412(6846):565]
REFERENCE   4  (sites)
  AUTHORS   Lowe,T.M. and Eddy,S.R.
  TITLE     tRNAscan-SE: a program for improved detection of transfer RNA genes
            in genomic sequence
  JOURNAL   Nucleic Acids Res. 25 (5), 955-964 (1997)
   PUBMED   9023104
  REMARK    This is the methods paper for tRNAscan-SE.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CM000666.2.
            On Feb 3, 2014 this sequence version replaced gi:224589816.
            Assembly Name: GRCh38.p7 Primary Assembly
            The DNA sequence is composed of genomic sequence, primarily
            finished clones that were sequenced as part of the Human Genome
            Project. PCR products and WGS shotgun sequence have been added
            where necessary to fill gaps or correct errors. All such additions
            are manually curated by GRC staff. For more information see:
            http://genomereference.org.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Homo sapiens Annotation Release 108
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11730
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            complement(<1..4)
                     /gene="LOC285500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon."
                     /db_xref="GeneID:285500"
     misc_RNA        complement(1..4)
                     /gene="LOC285500"
                     /product="uncharacterized LOC285500, transcript variant
                     X6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 long SRA read, and 95% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 2 samples with support for all annotated
                     introns"
                     /transcript_id="XR_001741929.1"
                     /db_xref="GI:1034643086"
                     /db_xref="GeneID:285500"
     gene            1..11730
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /note="aspartylglucosaminidase; Derived by automated
                     computational analysis using gene prediction method:
                     BestRefSeq,Gnomon."
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
     mRNA            join(1..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     6153..6206,8023..8122,9157..9290,10696..11730)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /product="aspartylglucosaminidase, transcript variant 2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: BestRefSeq."
                     /transcript_id="NM_001171988.1"
                     /db_xref="GI:285002252"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
     misc_RNA        join(1..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     8015..8122,9157..9290,10696..11730)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /product="aspartylglucosaminidase, transcript variant 3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: BestRefSeq."
                     /transcript_id="NR_033655.1"
                     /db_xref="GI:295849294"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
     misc_RNA        join(1..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     6153..6206,8015..8122,9157..9290,10696..11730)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /product="aspartylglucosaminidase, transcript variant X1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 59 ESTs, 69 long SRA
                     reads, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 67 samples
                     with support for all annotated introns"
                     /transcript_id="XR_001741155.1"
                     /db_xref="GI:1034638759"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
     mRNA            join(1..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     6153..6228,8015..8122,9157..9290,10696..11730)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /product="aspartylglucosaminidase, transcript variant 1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: BestRefSeq."
                     /transcript_id="NM_000027.3"
                     /db_xref="GI:285002250"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
     CDS             join(129..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     6153..6206,8023..8122,9157..9290,10696..10796)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Derived by automated computational analysis
                     using gene prediction method: BestRefSeq."
                     /codon_start=1
                     /product="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
                     isoform 2 precursor"
                     /protein_id="NP_001165459.1"
                     /db_xref="GI:285002253"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
                     /translation="MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAW
                     RALASGGSALDAVESGCAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAV
                     GDLRRIKNAIGVARKVLEHTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLA
                     RNCQPNYWRNVIPDPSKYCGPYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHI
                     AAGTSTNGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIAC
                     QKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVD
                     CI"
     CDS             join(129..255,2078..2231,2816..2928,3647..3759,4985..5099,
                     6153..6228,8015..8122,9157..9290,10696..10796)
                     /gene="AGA"
                     /gene_synonym="AGU; ASRG; GA"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; Derived by automated computational analysis
                     using gene prediction method: BestRefSeq."
                     /codon_start=1
                     /product="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
                     isoform 1 preproprotein"
                     /protein_id="NP_000018.2"
                     /db_xref="GI:285002251"
                     /db_xref="CCDS:CCDS3829.1"
                     /db_xref="GeneID:175"
                     /db_xref="HGNC:HGNC:318"
                     /db_xref="MIM:613228"
                     /translation="MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAW
                     RALASGGSALDAVESGCAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAV
                     GDLRRIKNAIGVARKVLEHTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLA
                     RNCQPNYWRNVIPDPSKYCGPYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHI
                     AAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYM
                     RRGEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSE
                     KNQPTEEKVDCI"
ORIGIN      
        1 agggacgcct gagcgaaccc ccgagagagc gggcgtgggc gccaggcggg cggggcactg
       61 gggattaatt gttcggcgat cgctggctgc cgggactttt ctcgcgctgg tctcttcggt
      121 ggtcagggat ggcgcggaag tcgaacttgc ctgtgcttct cgtgccgttt ctgctctgcc
      181 aggccctagt gcgctgctcc agccctctgc ccctggtcgt caacacttgg ccctttaaga
      241 atgcaaccga agcaggtgcg ggttggcggc ctgggcgggc ggctgcgccg cgagagcttg
      301 cgggtgggga tgactagccc gccccgctgc agtcacccgg cagggcggac ggaagagcgc
      361 cgggctgggc cgggcctcgc ggtcccgccc tctaggtctt cccgagtctc cagcgccgct
      421 cagtctcttg caagtggcct ttactgcatc ctccccacct accgctgttg cattttaggt
      481 cctcccttca tgcagccccc agcgcaatgt attttccacc ctgctgctga ccatagttat
      541 ggcctttgtg ctttaatcaa gtagcagcta cgcttttctg cctgacagtc ttttcacggg
      601 ctgtgtacgt ctccacctct cgtttctaat ccttcacttc tttgcaattt tgtagacgac
      661 taatagtgtc ccagccatag cctactcttt tcccatttac tttttttgcc acgtgttgtc
      721 atactttacc tgccacttag aattcaaggt tccaaccttt gctgtacatt cacactatct
      781 ggggagcttc tcaaaaatca tcctgccggg gcccacctcc tgtgactgtg atctaactgc
      841 tggaatcagg gccactgttt ttctttaaaa agctccctag gtgatttcga tttgcagaca
      901 gggttgagaa ccactaagct aaggtatcac ctcttccagg aagcgttccc tgacttaact
      961 gccctcgtgt ccagaatgag ttaggttcct gccttctaca ccttgttaat agcctttacg
     1021 taccattatc ttggcatttt cgcattgtac tatgcttgtt tctttcattt gcttaatgac
     1081 cagaagagtc attttcagac ccctcctcct ccatctgagg ttgctaacgt attaactttc
     1141 tagggcagaa ttggctccag aatttggtgg cagtgcatac gattcagaga aaatgaagaa
     1201 gcaggctgtg agaaagatat tcccagccat aatgagacga aaagaaattg catcagcctg
     1261 ggcgggggac agttctgtgt ttaagttgcc tgtattgaaa gagggaactt gcgtaaatac
     1321 actttcaagc ctgtaggtgc tgtagtgttt accaaccaga gcacccactc ttcaaggaat
     1381 tctgttgtta ccagaaaaga aattgtccat caaagaccct tccccccaca cccccaaatg
     1441 tatgggatcc tggctctgct acttaccagc tgtgtgacct taaactaact gcctgacctg
     1501 tggctctgtt tacttttctt taaaatgagg gtcgtgattg tacagtacct accacagaag
     1561 ctgttatgaa gactcaatga actaatccat atgaagtcca cgttgtaatt gtttgctgtt
     1621 cagtattatt aagacttcct gggataggtg ttacctcaat acacatatca attatgcata
     1681 ttttaatcta atgatgcaga agaaatgtgt gaagaaggct gcggtttagt ggatttttta
     1741 tttaactgcc ttttagtggt ttcgattgta ccttttaaaa taaaggaggg gatactgatt
     1801 tcgtttctcg cacacagaag agatagatat tagtaagtga aaaaaaaaaa aaccttcagc
     1861 ttgcaccaat agccagtttt ttgagttctt ctgataacta gttaaataat tttgactctt
     1921 cactgactcc tttgtaacac ttgataaact aatgtgttaa aaaatcagct taactcagta
     1981 aatgtgaaaa agttgttaaa ttggagttgg tttgttgcat ttggcattga aaaaaaaata
     2041 tatatataaa caagcattat tgggatttga ttaacagcgt ggagggcatt agcatctgga
     2101 ggctctgccc tggatgcagt ggagagcggc tgtgccatgt gtgagagaga gcagtgtgac
     2161 ggctctgtag gctttggagg aagtcctgat gaacttggag aaaccacact agatgccatg
     2221 atcatggatg ggtaagaaca ccgttcaggt cctatttatt atgttgagtt acatttagag
     2281 ttgtggtctt ctgagagcaa gatgaaagaa tgcatgagtt ttgacacaga tcaaaacccc
     2341 tagcttatta tacttgacct ttctaaacac agtttccctc tcaactgaaa aaaaaaaatc
     2401 agagtaatag aaatatcaca tggagagata ggtagtccct tagaactggg agaatgccaa
     2461 gctaaaaaac tatgtctctg accttataaa caatcattta tctgctgtcc acaaatgctg
     2521 tggtttgcct gacctgaagc cttcaggccc ctttcaaaag ccatatttaa aattagcttg
     2581 gagaaactga gaattttagt gctgttgtgg tacatggcaa gttgattttc tatttttttt
     2641 ccttaatttt gtctgattgt gggaatctat atgaacttcg tggatgtgct gtcacttctg
     2701 tgttaagatg gtggagttta accgcaaaac actattgatt ggagaaaagc aatgttttta
     2761 atctatgaac ctctgaaaac tccttaattc ctaactgcat tctattttct tgcagcacta
     2821 ctatggatgt aggagcagta ggagatctca gacgaattaa aaatgctatt ggtgtggcac
     2881 ggaaagtact ggaacataca acacacacac ttttagtagg agagtcaggt atttttttaa
     2941 ctacactgaa attttttcta gtcttttgac tatagttttc actgaaaaat agtacaaaat
     3001 catggataaa accagatcta agttcaaatt ccagctgttt tacttaacat ctattgaact
     3061 ggataagtaa cttttaaatc tctttacttc ttcatctcta agaagaaggc aatggaagtt
     3121 ttgagacgga gtttcgctct tgtcacccag gctggagtgc aatggcgcga tctcagctcc
     3181 cgacaacctc tgcctcctgg gttcaagtga ttctcctacc tcagccttcc aagtagctgg
     3241 gattacaggc acgtgccacc atgcccagct aatttttata tttttagtag agacggggtt
     3301 tcaccatgtt ggccaggatg gtctcaatct cttgacttcg tgatccaccc gcctcagcct
     3361 cccaaagtgc tgggattaca ggtgtgagcc accgcgcctg gccgggacga gaactcttat
     3421 aatgcatgcc ccaaaggttt taagtggatc tgttttagga aaggcataag gaaatcgaag
     3481 gtctaaaaat tgagtctctt aaaactgttc atgtgtgaat attcctttga aagtctttgt
     3541 gtagctcact taagatgctg ctgacccaga atgtctctag tacatatatt tttgttgaaa
     3601 agacaatact tgaataattt atactttcct tttttccaat ctccagccac cacatttgct
     3661 caaagtatgg ggtttatcaa tgaagactta tctaccactg cttctcaagc tcttcattca
     3721 gattggcttg ctcggaattg ccagccaaat tattggaggg tatgcacaca tttaatttaa
     3781 aaaaataagt taattgaaaa tattcagtga catcctttct gctcagtgtt gcctgcctgt
     3841 tgtccagggt actggttagc atcctggctg tacattagaa ctagtggttt tagttgactc
     3901 tccaggtatg gatgttcctg aaacacctct agctgcattg ggtgcatatc cagcatggag
     3961 agctactggt ctctcacaat agttttcaaa ctgaagtttc tgccatgtgg aggtggctgc
     4021 ctcaatcagg gctgctctgc ttgtatttct ttctaactaa gtctaaaaaa tcagtttgga
     4081 aactatgagt ctaaaatatt tcttagattt tacgtgcagt gtatccagta tcttgttctt
     4141 gacttgagga catgtaatat tacatgtcta gtatgttacc agtggaataa tttttcttta
     4201 atgagacttt tggcataaat cagtttgcct ttgccgtaca gggtccttct gtgggatatc
     4261 ttagtctctc atctatttct tccctaagtc ctaattactt tcgagtagcc atcaagtcag
     4321 aagtcccttg ggttagcact tgaaagaggc taatcataaa acgaagttag gggaggcacc
     4381 tagcgcactg atgtgtaaga catgaggaat aggaataggt ttcttgcttt aataccagtc
     4441 tacatacaca acctaaattt atgagtttgc attatattct tgagcccttt agatttataa
     4501 aggaatctta aagcacaact tagaatatat tcacataaac ctagctttga agaaacaata
     4561 aaagctttta aaacatattt tactttaagt ctcagaattc tttggccaag gaacaaattt
     4621 ctgaaattta aaggtccagt gtgtatctaa tttctttaag gattaatatc taattttaaa
     4681 aaattttact attgtgttga gaattttaga tatatataaa gagagaaatt agggacctgt
     4741 gtcatgcaat atagatacct cacctgtatt atttaattct tagactagaa tggatattca
     4801 gtaaaattat ttatcttatt tgtttttata taagacttag tgatttctta gcttttaatt
     4861 cttatcttta agttaccaga tgtctttttt tggtttcttg ctagtgttta gcgattgtac
     4921 ataatttctt ggcaatttct aaaaataccc tttgtaagaa ataaaactta aatcttgttt
     4981 acagaatgtt ataccagatc cctcaaaata ctgcggaccc tacaaaccac ctggtatctt
     5041 aaagcaggat attcctatcc ataaagaaac agaagatgat cgtggtcatg acactattgg
     5101 taatttgcct tttgtgcagt ttttatggat aaagtttagt taattatctt cctgtagctc
     5161 ttccctattc ttctaccaga agttgatttt gattgtttta actgccaatt aagtgtgcct
     5221 ctctatagat agatccatct tgtcttagga tctgtataaa atttggcaaa ttatttatac
     5281 aagacaccta aaacccaatg actattcact tgcggatttt taaatcttta tttgacattt
     5341 cattttttgg cagttttatg ttgctgtatt ttagtgacct taaataactt tttccaagtt
     5401 acaatgttga aaatttacat tagtctatgt cttagtttgt ttttcgctgt tataacagac
     5461 taccacagac tgggtaattt ataaacaaaa gtttatttgc ctcacagttc tggagcctga
     5521 gaagttcaag aacagggcac tggcatctgg caagggccat cccaaggtgg aagtcaagag
     5581 aatgagacag gaaatcgggt agaactcatc ctttatatca ggaacccact ccctgcgata
     5641 atggcattaa gcccttttag cctaatcgcc tcttaaaggc cccacctgtt aataataatt
     5701 aataatgtta attgcctgtt atagtggcag ttaacaaaat acccagactg gatggcttat
     5761 aaacaacaga aatttatttc tcacagttac ggaggctggg aagttcaagg tcaaggcgct
     5821 ggcaggttca gagtttggag acagcttgtt ttcctggctc atggatggcg tcttcttgct
     5881 gtgtcgtcac gtggtggaag gggcgaggaa gctctctggg gcctcattta taagggatga
     5941 attccattca tgggggctct gtcctcatga cctaatgagc tcccaaaggc ctcacctctt
     6001 gataccatca ccttgtggaa taggatgttg acatgaattt gggggaacac aaacattcag
     6061 agcacagcag ttattaccag ttgctcaatt atttggttat atttgaggta aactttatac
     6121 acctacagtg attttttttt tttaacttct aggcatggtt gtaatccata agacaggaca
     6181 tattgctgct ggtacatcta caaatggtat aaaattcaaa atacatgggt tagtgtttcc
     6241 aaaagaacag agctctcaaa tatacactga atgcagagca atatatgccg ggtgctatgg
     6301 gggttgcaaa gcacagccct agtctcacag ctgcgatgaa tgagtgtgaa agaaaatgca
     6361 gtactctctg ctgagtgcca caggagaggg agtcacagcc agtgctatag ggtttagggg
     6421 tggcagaggt gatctcttta agctggggta gttaggaaca ccagtaaagt gatgcttgga
     6481 gctcagccct gagtcatggt agttgaggtt cagcgctcct actggctagg aaagttgtgt
     6541 gtgtatatgt gtgtgtgtgt tcagggctcc cactggggtg tgtgtatgtg tgcatgtgtt
     6601 cagaactccc actggcttgg aaagaagggg tgtgtgtgtg tgtgtgtgtg tgcgtgcacg
     6661 cagaactact ggcttggaaa gaaggggtgt gtgtgtgtat gtgtgcgtgt gcgtgcacgc
     6721 tcagggctcc cactggtgtg ggtgtgtgtg tgtgtattca gggctcccac tggctaggga
     6781 agaaggggtg tgggggtgtg tgtgtatttt ggggtagggg aagtggtatt ggaagataag
     6841 actacaaggg aagactgggg ccagatttaa ggagtcttaa gtcagttgaa ggcattctgg
     6901 atttaatttt gaaatagaaa agcattaaac atttcttact agaaaaaaat ctggtaaaag
     6961 tttggcacat tacataggaa gcggaaatag attatagatg agggaaacca attttgaaca
     7021 tgttgcaatc atctggaaat tagatgataa aggatggtaa taatagaata gtcactgtaa
     7081 atctgtgcca tcctggtata tacctggctg ataacaagtt cttttaaaaa attaatttta
     7141 atgacaatga aaattatgtg tatttgtggt gtacaacatg atactttgat atatgtatat
     7201 gttgtagaat ggctaaatca agctatttaa cttattatct cacagaccta ttttattatg
     7261 gtgagaacac ttaaaatcta cttagcagtt ttcagctggg tgcagtggct cacgcctgta
     7321 atcccagctc tttgggaggc caaggcaggc agatcacctg aggtcaggag ttcgagacca
     7381 gcctggccaa catggtgaaa cccagtctct actgaaaaaa aaaaaaatac aaaaaattag
     7441 ctgagcttgg tggttcgtgt ctgtagtccc agctactcag gaggctgagg cagggagaat
     7501 cgcttgaacc caggaggcgg aggttgcagt gagccaagat caatgccatt gcactccagc
     7561 tgggtgacag agcaagactc ctgtctcaaa aaaaaaaaat ctacttcgca gttttcaaat
     7621 gtgcactcta ttgttattaa ccttagtcag catgatccgc agtaggcctc tggaacttac
     7681 cctcctgcct aactggaatt gtgtgtcctt tgacccgcat ctcgccaggt ccccctcccc
     7741 ccagcctcca gtaaccacca ttttagtctc tgtttctgtg agttcagctg ttgtacactc
     7801 cacgtctgat aacaaattct tacataatta atgcaggttt gtgaaaacct tagttaaaaa
     7861 actaatgaag acctgttctg tctttgttcc gatgaagaat ttacttaaaa cggtatcaga
     7921 ggctaagtgg aactatccct tatttggaac agcttatgac ttaatgtgtt ttacactcga
     7981 tttcctgccg taaattgtta ataccctctc aaagccgtgt aggagactca ccaatacctg
     8041 gagctggagc ctatgctgac gatactgcag gggcagccgc agccactggg aatggtgata
     8101 tattgatgcg cttcctgcca aggtatgact tcttagtttg tgaattttag agacctttgg
     8161 agaagatatt tttttctttt aagatagaaa ataatttttg aggctgggtg cagtggctca
     8221 cgactgtaat cctagcattt tgggagactg aggcaggtgg atcacctgag gtcaggagtt
     8281 tgagaccagc ctggccaaca tggtctcgaa ctcctgaccg tttctactaa aaatacaaaa
     8341 aatttagctg ggcatggtgg cacaagtcta tagtcccagc tactcgggag gctgtggtag
     8401 gagaatcgct tgaacctggg agacagaggt tgcagtgaac caagatcgcg ccactgcact
     8461 ccagtgtggg caacaagaat gagactgtgt ctcaagaaaa taaaagaaag aaaacataat
     8521 ttttgtattg tgtaacctga atttctgtgc acaagagctt cttagaaact gcatacaaac
     8581 ttgttgccta tcattttgat aatgataatc attcaagtta agtaatcata gtcctgtgaa
     8641 ataaagtagt atttctcacc ctgcttccca gatgagaata cttatgatct atttagtaat
     8701 tgatgtaaag ctactgagta aaggagctgt gataattgat ggtaaaagta ggaagtgcag
     8761 tcatcgtgta cctttaacca ccctagctag atgttgtgcc catgcacact actttcccct
     8821 ttgattgtag ctgtttttct cattgaaaat ctgtattctt tttgagttct ggccattaca
     8881 tttgactgtc ggtatcatta ctgacagtta ttcagccaaa gccaaaaata atattccaca
     8941 tctgaaattc atgggtggat tagttgaaaa gatagactct gtatcaaagt ggacttgctt
     9001 tgtggatgct ttaacagaag taaccgactc ttgttcattt atgtgtattc tatcacatgt
     9061 ggcaattttg gtggttttaa tttctaactt caagtaaccc aatttggagt tagtatttat
     9121 tctgagacac taaggtttca cctctgtttc aatcagctac caagctgtag aatacatgag
     9181 aagaggagaa gatccaacca tagcttgcca aaaagtgatt tcaagaatcc agaagcattt
     9241 tccagaattc tttggggctg ttatatgtgc caatgtgact ggaagttacg gtaagttgtg
     9301 tttggatttt gtatttgtgt gaacttccaa atatttctaa aacatacact ttttaaatat
     9361 tgttttgtac aatacactat attcaataga aaaagagact ccttaagtgg gcattgagta
     9421 aatgttcatt gatgatctca agacccacag cgttaaaaat atacctaaaa gcctctttgg
     9481 attgactgct ggtagttatg acccagtctc tgactagtag ttcttatctt tcacatgtgt
     9541 cttaaatgaa gtttagcttc agctccagta cacgttgaca taggctaatc tagtcaaatg
     9601 tttatactaa ttaaaaatag acaaggataa attatcttcc ctatttcttt tctattcatt
     9661 atttaaatgc ctcagccatt tagatcttct cggggctcca aagaacaaaa tgtattacta
     9721 attagtaaac cgaagaggtt agcagaatta tttttgcact gtttgaggct tgtctttcac
     9781 ttcatttact ttccatatga gcctatcaca gtttcaaagc attttaagat cagccactgc
     9841 tgattctcat tagtgaattt tcagatgggg aagatacaca gcttactgat caatatgact
     9901 tattaggttg gactgcttat tattgttctt tgatctttta cttcccacag ttctatattt
     9961 gaaaaacttg tttgaggaat gctttattct tttttaagca ctaagacaca aaagtcaata
    10021 aaaattatga aggggaaaag ctttatgtat caaataaggc agttctattg attccctctt
    10081 aagaaataaa ccttattaga aagctcaaag ttggatttaa cagaatgaaa aaaatgataa
    10141 ttatataatt gtggatgaat ttacaggtga ctagtttctt ctatttaatg accaaagagg
    10201 accctccccc aggtgtttga gcatgagaag atgaacttga ttagacaaag catcttgaca
    10261 aattactctt gactcttcct gtgagagtag aagaataggg agcaatggtg gggtatgggg
    10321 ttatgaatga atgatgagaa tgttctagtg gctagagaaa taaaatgtgg gagatgtgcc
    10381 tgaatagttt tttctaagaa aaacacgtaa gaacagttaa ataatcgtag cagtgacagc
    10441 atgtgtatag atcaacaaca acaacaaaaa ccagccagtt ttctgaagtt caaagagata
    10501 gtttaccagc tacctcattc ctttcatgga ctgttcactg ctcagttctg aggaggatga
    10561 cactagtgta tttccatgtg gcttagacat aaggtataca gtagccagtg tctagtcaaa
    10621 taagcagtat ctgtattggt tataaatatg tgcatcctat agttcaccaa acttctttct
    10681 catttttggc cccaggtgct gcttgcaata aactttcaac atttactcag tttagtttca
    10741 tggtttataa ttccgaaaaa aatcagccaa ctgaggaaaa agtggactgc atctaatcca
    10801 tctttactgt caacatctgt atttaaagaa gaaagaaaca aaggctgaaa aggctgctca
    10861 ctctcatcat ctagtgttcc tcatgtgttc taaagtcttt ttgtaaaata aacacaaaaa
    10921 taaatttatg ttgaattggc actttctata tctgaaattg tattatctat ttttatttaa
    10981 cctttcttat attatctgaa gatgaatatg tatgtggctg tattttgtat atatttaagt
    11041 tttaagtgac acttggattt ctgatcagtg ttgcaaaaaa ttgctacttt gagatttatt
    11101 tccacagtga tatattaaac ccaaaaggaa tcatcatatt tggatgctta aaatagagta
    11161 tacaagtttt ttagacccaa agaaaaaaac agcagagtct cagcatgatc agtcctgatt
    11221 gaatttcatt atgtcacagt gatgcatgtc ttagcactga ttattggttt tacttaatat
    11281 tccctaaaaa cttgaggaag gaagatgata gaacatgaga tactctttgt tttgtacata
    11341 ctagaaaata cagctatctt ctgatgagca attgtgttga ttttctttgc ttttttcctc
    11401 ttatggagct ctcagtgtgt gaaagttcta aagccacaag aatcaatgat gttttagctg
    11461 ctaatattta gtattgatcg tttcttttaa aaatgatttg gggaacttga tctgtactgt
    11521 aattttacta attccttgtg cagaggtggg tatggcaatt agaagtcaag aaatgggttg
    11581 tttagcttgg tttgtttccc taacttctga ttaactctct gtatgacaac tctacagaag
    11641 ttgtgcgcgt gctttctcag cagcattttt ccttcaaaat catcttttta atcaacagtc
    11701 attaataaat gtacatgtac gatattcaaa
//

